The Role of Virus in Inner Ear Disorders
Experts disagree about the different concepts of how to explain the etiopathogenesis of inner ear disorders such as idiopathic sudden sensorineural hearing loss or Ménière’s disease. In this issue the pros and cons of the viral hypothesis, based on epidemiological, serological, and histopathological studies in humans and animals and on clinical trials of antiviral therapy, are discussed. Also new theories are introduced, in particular regarding the cause of idiopathic sudden sensorineural hearing loss which might result from abnormal cellular stress response. This issue will be indispensable to any scientist involved in the research of inner ear disorders, and it will help ENT physicians to better understand the viral hypothesis and why the conclusions of the many studies published on the topic are still controversial.