This volume contains the proceedings of the First International ICST Conference on Digital Business (DigiBiz 2009), hosted by City University London in London, UK. This annual event had the main objective to stimulate and disseminate research results and experimentation on future Digital Business to a wider multidisciplinary forum that would allow the participants to cross the boundaries between research and business. The scientific offering in e-business, e-commerce, and ICT in general is quite broad and spans many different research themes, involving several communities and me- odologies. The growth and dynamic nature of these research themes pose both ch- lenges and opportunities. The challenges are in having scientists and practitioners talk to each other: despite the fact that they work on similar problems they often use very different languages in terms of research tools and approaches. The opportunities on the other hand arise when scientists and practitioners engage in multidisciplinary d- cussions leading to new ideas, projects and products.