MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.
The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
A comprehensive overview of one of the largest pore forming proteins superfamiliesA special chapter on methodology allowing the study of mechanisms of pore formationSeveral novel data reviews which provide new insights into the distribution of MACPF/CDC proteins throughout biologyIn depth perspectives on MACPF/CDCs from multiple fields of study: medicine, biology, biophysics, applications-based, technical development