Statistical Modelling in Biostatistics and Bioinformatics
This book presents selected papers on statistical model development related mainly to the fields of Biostatistics and Bioinformatics. The coverage of the material falls squarely into the following categories: (a) Survival analysis and multivariate survival analysis, (b) Time series and longitudinal data analysis, (c) Statistical model development and (d) Applied statistical modelling. Innovations in statistical modelling are presented throughout each of the four areas, with some intriguing new ideas on hierarchical generalized non-linear models and on frailty models with structural dispersion, just to mention two examples. The contributors include distinguished international statisticians such as Philip Hougaard, John Hinde, Il Do Ha, Roger Payne and Alessandra Durio, among others, as well as promising newcomers. Some of the contributions have come from researchers working in the BIO-SI research programme on Biostatistics and Bioinformatics, centred on the Universities of Limerick and Galway in Ireland and funded by the Science Foundation Ireland under its Mathematics Initiative.
Presents new implications for statistical analyses of frailty survival models with structural dispersionFeatures new methods of model-based clustering in Bioinformatics as well as of detecting genetic sweeps in population geneticsProvides new insights into non-proportional hazards survival models and the use of H-likelihood methodsPresents results on the new class of HGLMs - hierarchical generalized non-linear models