Cellular Senescence and Tumor Suppression
As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.
Will cover many of the recent findings in the area of senescence and cancer, including chapters that discuss telomeres and senescence signals, the senescent phenotype, and the physiological effects of senescence, including therapeutic applications