Reverse Genetics of RNA Viruses
Reverse genetics, the manipulation of the DNA of RNA viruses to create a modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells over the past fourteen years. Since most severe viral human and animal pathogens are RNA viruses, including those responsible for polio, hepatitis and influenza, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases.
Written by a team of international experts in the field, this book provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. From influenza A virus vaccines, to fluorescent measles virus and quasispecies, this guide explores the progress researchers have made in our current understanding of viral disease and considers where possible applications may lead in the future.