In Neurotherapeutics: Emerging Strategies neuroscientists, clinicians, and industry-based pharmacologists and chemists review emerging approaches for the treatment of diseases of the central nervous system. The contributors-all key investigators of novel therapeutics-focus on developing rational strategies for drug design based on the new understanding of the underlying pathophysiology of central nervous system diseases. In the process, the contributors review the efficacy and mechanisms of current treatments as well as the latest research results and their potential therapeutic impact. Common to all chapters is the promise held out by newly cloned receptor subtypes of therapeutics with improved selectivity and potency. Also explored is the potential for novel therapeutics from a developing understanding of signal transduction. The diseases discussed range from affective disorders and Alzheimer's disease to Parkinson's disease and schizophrenia, as well as anxiety, panic disorders, stroke, epilepsy, and Huntington's disease.