The Eukaryotic Replisome: a Guide to Protein Structure and Function
High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
Takes the reader on a guided tour of the structural biology of the eukaryotic DNA replication machinery, the first time that this has been done in a single volume Individual chapters focusing on the three-dimensional structure and function of key components written by leading experts in the field An additional chapter providing a comprehensive overview of the evolutionary distribution of key proteins and protein complexes.