Gene centric genetics is the main framework of current biology. Human and cancer genome sequencing offered the promise of solving the mysteries of life and producing a cure for cancer. Paradoxically, the more we learn about DNA sequences, the less we seem to understand how genetic systems work in evolution and disease. In this book, the genome theory is introduced, challenging the conceptual framework of current genetic approaches, addressing the limitations of well accepted biological theories and searching for new answers. This book outlines the concepts of 4D-Genomics by illustrating the differences between genes and the genome; parts inheritance and system inheritance; artificial selection and natural selection; and linear experimental systems and the realities of non-linear nature. 4D-Genomics differs from standard genomics approaches as it combines the 3-diminsional genomic topology that is crucial to system inheritance with the time to understanding how evolution works on the genome package. By developing the concept of 4-D genomics this thought provoking book addresses many biological paradoxes and offers new insight on topics from cancer to the function of sex and to a new evolutionary theory.
First book to outline the new genome-based genome research
Points out new direction in Genome research
Examines three-dimensional interactions of the genome with the components of the cell, evolution and varying patterns of expression over time